Effect of adriamycin on calcium current in single cardiac myocyte of gunea pig
- VernacularTitle:阿霉素对豚鼠单一心肌细胞钙电流(I_(Ca-L))的影响
- Author:
Yulan BAI
;
Jinming LI
;
Guiying CUI
;
Qianzhong ZHANG
;
Yukun HAN
;
- Publication Type:Journal Article
- Keywords:
adriamycin;
L type calcium channel current;
patch clamp;
cardiac myocyte
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To analyze the mechanism of the adriamycin induced cardiomyopathy. METHODS The patch clamp technique in the whole cell recording was used to study the effect of adriamycin on L type calcium channel current( I Ca L ) in the isolated cardiomyocyte of the guinea pig. RESULTS The current voltage( I U ) curveshowed the bell shape in the control and in 0 1 mmol?L -1 adriamycin. Their peak potentials were about +10 mV. The amlitude of peak calcium current increased from (-0 93?0 05) nA to (-1 31?0 08) nA( P
