Inhibitory effect of domestic leuprorelin acetate microspheres on experimentally induced endometriosis in rats
- VernacularTitle:缓释醋酸亮丙瑞林微球对大鼠子宫异位内膜的抑制作用
- Author:
Xinhong XU
;
Linghong GUO
;
Qinyan GONG
;
Linai CHEN
;
Minghui YAO
;
- Publication Type:Journal Article
- Keywords:
leuprorelin;
microspheres;
endometriosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of leuprorelin acetate microspheres (LE ms) on endometriosis in rats, and compare the efficacy of material drug (LE), domestic and imported LE ms (enanton). Methods Endometriosis was induced by endometrial implant in rats. Then the animals were treated with LE (20 ?g?kg -1 ?d -1 ? 28 d ,sc), enanton(20 ?g?kg -1 ?d -1 ,sc)and domestic LE ms ( 2,20,200 ?g?kg -1 ?d -1 ,sc). Results Implants in control group continued to grow, while those in groups treated with drugs shrinked significantly, and domestic LE ms could produce dose dependent inhibitory effect on the growth of endometrial implant in rats. Conclusion The domestic LE ms at the single dose of 20 ?g?kg -1 ?d -1 has the same effectiveness as enanton and routine injection with the same does of LE for 28 days.
