EFFECTS OF ANTIOXIDANT VITAMINS ON BLOOD LIPID METABOLISM, LIPID PEROXIDATION AND mRNA EXPRESSION OF SCAVENGER RECEPTOR IN RATS
- VernacularTitle:抗氧化维生素对大鼠脂代谢及清道夫受体表达的影响
- Author:
Yanqiu CHEN
;
Yan YANG
;
Yongping CUI
;
Xizhong ZHANG
;
- Publication Type:Journal Article
- Keywords:
antioxidant vitamins;
lipid metabolism;
lipid peroxidation;
scavenger receptor;
dot hybridization
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of VE and VC at different dietary levels on plasma lipid metabolism, lipid peroxidation and mRNA of scavenger receptor (SR). Methods:Male SD rats, fed purified and cholesterol enriched diet, were divided into five groups(12 rats per group). The experimental groups were fed diets with either VE(150 or 350 mg/kg diet) or VC (1 000 or 2 000 mg/kg diet) respectively. The experiment lasted 56 days. Results:Compared with control group, both VE and low dosage VC could significantly lower the concentrations of total cholesterol(TC), low density lipoprotein cholesterol(LDL C), atherogenic index (AI),Apo B and lipoperoxide, and increase the levels of high density lipoprotein cholesterol (HDL C), and inhibit the expression of SR mRNA..Conclusion:VE and VC can decrease the concentrations of serum TC and LDL C,restrain formation of Ox LDL and expression of SR mRNA.
