Relation of vascular endothelial inflammatory reaction and atherosclerosis and its enlightenment for research of anti-atherosclerotic drug
- VernacularTitle:血管内皮细胞炎症反应与动脉粥样硬化的关系对药物研究的启示
- Author:
Yinglin LIU
;
Gengtao LIU
;
- Publication Type:Journal Article
- Keywords:
vascular endothelial cell;
atherosclerosis;
inflammation;
NF-?B
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The accumulated evidence indicated atherosclerosis (AS) is associated with a chronic inflammatory reaction. Either by secretion of inflammatory mediator or by modulation of expression of adhesive molecules onvascular surface, vascular endothelial cells play a key role in initiation and amplification of inflammation in artery. The NF ?B transcription factor family is a pleiotropic regulatory of endothelial cells activation and the multiple genes relevant inflammatory cytokines are regulated by NF ?B transcriptional activation in endothelial cells. Selective protection of vascular endothelium and regulation of endothelial inflammation may be rational as the target for anti AS.
