Progress in Cbf?1 gene and its regulation
- VernacularTitle:Cbf?1基因及其调控研究进展
- Author:
Zhousheng XIAO
;
Honghao ZHOU
;
- Publication Type:Journal Article
- Keywords:
Cbf?1;
osteoblast differentiation;
signal transduction pathway;
expression regulation
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Cbf?1 gene encodes an osteoblast specific transcription factor that regulates osteoblast differentiation and bone formation. The Cbf?1 gene contains 9 exons, however, the alternative splicing of its exons leads to genesis of multiple Cbf?1 isoforms with differences in transactivation potentials. Several signal transduction pathways, such as Ras MAPK pathway, cAMP pathway, or Smads DPC4 pathway, are involved in regulating Cbf?1 activity or its expression. These studies open new doors in pharmacological control of bone formation and gene or cell therapy of slowing the progression of osteoporosis.
