Progress in synaptic plasticity and related proteins
- VernacularTitle:突触可塑性与相关蛋白研究进展
- Author:
Xiaoying WANG
;
Juntian ZHANG
;
- Publication Type:Journal Article
- Keywords:
GAP-43;
NCAM;
synaptic plasticity;
neurite outgrowth
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The growth associated protein(GAP 43) and neural cell adhesion molecule (NCAM) play an important role both in promoting neurite outgrowth and synaptic plasticity. GAP 43 is a neuron specific phosphoprotein that is highly expressed during the development of the central nervous system, nerve regeneration and the modulation of synaptic function, and it is frequently used as a marker for sprouting. GAP 43 may be involved in G protein interaction, membrane binding, calmodulin binding and protein kinase C phosphorylation. The various interactions, specified by the structural domains, are thought to underlie the role of GAP 43 in synaptic plasticity, participating in membrane extension during neuritogenesis, in neurotransmitter release and long term potentiation. NCAMs involve in the intracellular signaling cascades and stimulate the axonal growth, GAP 43 function is essential for NCAM stimulated neurite outgrowth and that much of this appears because of the phosphorylation of GAP 43 via the FGF receptor dependent stimulation of arachidonic acid. NCAM can accelerate the phosphorylation of GAP 43.
