Mechanisms of action of protein kinase C in myocardial preconditioning
- VernacularTitle:蛋白激酶C在心肌预适应中的作用机制
- Author:
Haixia ZHANG
;
Guanhua DU
;
- Publication Type:Journal Article
- Keywords:
preconditioning;
protein kinase C;
calcium;
adenosine;
K ATP channel;
mitogen-activated protein kinase
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
PKC plays a pivotal role in the mechanism of myocardial preconditioning. After preconditioning, PKC is activated and translocated to membranes and cytoskeleton structures by multiple endogenous substances such as adenosine, calcium, etc. Recent studies imply that MAPK carries the signal from PKC to the mitochondria K ATP channel and thus protect the heart.
