Tumor necrosis factor-alpha and heart diseases
- VernacularTitle:肿瘤坏死因子和心脏疾病
- Author:
Hong CHEN
;
Wenlin LIAN
;
Li CHEN
;
- Publication Type:Journal Article
- Keywords:
tumor necrosis factor-alpha;
congestive heart failure;
myocardial ischemia-reperfusion
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Tumor necrosis factor alpha (TNF ?) is a pro inflammatory cytokine produced primarily by mononuclear phagocytes in blood and different tissues. Current data indicate that adult myocytes can also produce TNF ? in the course of various heart diseases, such as congestive heart failure, myocarditis, ischemic heart disease, dilated cardiomyopathy, and septic cardiomyopathy. Elevated TNF ? is considered to be contributive to the pathophysiology of these diseases. Methods concerning anti TNF ? therapy and their clinical application are the on going investigations.
