A comparison of inhibition of pravastatin on HMG-CoA reductase with enalapril and verapamil in SDR and SHR liver
- VernacularTitle:普伐他汀、依那普利和维拉帕米对SDR和SHR肝脏HMG-CoA还原酶抑制作用的比较
- Author:
Weibo LUO
;
Faneng SUN
;
Yiping WANG
;
- Publication Type:Journal Article
- Keywords:
pravastatin;
enalapril;
verapamil;
HMG CoA reductase;
liver microsomes
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To compare the inhibition of pravastatin on HMG CoA reductase with enalapril and verapamil in SDR and SHR liver. METHODS The liver microsomes were prepared by ultracentrifugation, the HMG CoA reductase activity was determined by radioactivity in vitro. RESULTS Pravastatin inhibited HMG CoA reductase, and its IC 50 value was 0 28 g?L -1 . The inhibitory rate of pravastatin on HMG CoA reductase in SDR and SHR liver were 51 40%?3 98% and 63 40%?4 14%, respectively (P
