Oridonin induces apoptosis in human leukemia HL-60 cells
- VernacularTitle:冬凌草甲素诱导HL-60细胞凋亡
- Author:
Jun WANG
;
Qingyun LIU
;
Haiying HU
;
Qixia YE
;
Yu ZHANG
;
Tanmu ZHANG
;
- Publication Type:Journal Article
- Keywords:
Oridonin;
HL 60 cells;
apoptosis
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study oridonin induced apoptosis in human leukemia HL 60 cells. METHODS Cell morphology, agarose gel electrophoresis and flow cytometry were used. RESULTS Oridonin had significant apoptotic inductive effect on HL 60 cells in both concentration and time dependent fashion. The marked morphological changes including condensed chromatin, nuclear fragmentation and apoptotic body were observed. Typical DNA ladder in agarose gel electrophoresis and pre G 1 peak in flow clytometric analysis were also observed in the cells exposed to Ori. CONCLUSION Oridonin can induce apoptosis in human leukemia HL 60 cells.
