Comparing therapeutic effects of intratumoral injection of norcantharidin poloxamer 407 slow released preparation and absolute ethanol on primary liver cancer
- VernacularTitle:去甲斑蝥素-泊洛沙姆407缓释剂和无水乙醇的肝癌瘤内注射疗效比较
- Author:
Zhe CHEN
;
Xiaofeng ZHAI
;
Dong JIANG
;
Changquan LING
;
- Publication Type:Journal Article
- Keywords:
norcantharidin;
poloxamer;
delayed action preparations;
liver neoplasms;
drug therapy
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the therapeutic effects of norcantharidin poloxamer 407(NCTD P407) slow released preparation on advanced primary liver cancer by local intratumoral injection. Methods: Fifty six advanced primary liver cancer patients with maximum diameter from 6 to 12 cm were randomly divided into test and control groups. Patients in test group (29 case) were treated by NCTD 407 intratumoral injection under ultrasonic and patients in control group (27 case) by PEI (percutaneous intratumoral absolute ethanol injection). Clinical therapeutic effects were observed respectively and compared. Results: Twelve months survival rates of patients in 2 groups were significantly different, being 31.0% in test group and 22.2% in control group ( P 0.05) in 2 groups. No evident poisonous and side effects were found in either test or control group. Conclusion: NTCD P407 administration exhibits therapeutic effects in relatively big advanced liver cancer because of the high concentration and prolonged action in the tumor foci, its comprehensive therapeutic effect is better than that of absolute ethanol administration. [
