Expression of PTN gene in glioma, hepatoma and laryngeal squamous cell carcinoma
- VernacularTitle:人PTN基因在脑胶质瘤、肝细胞癌、喉鳞癌中的表达研究
- Author:
Juxiang CHEN
;
Yicheng LU
;
Rong TANG
;
Xiongying FANG
;
Fang XIA
;
Jianchun LIAO
;
Meiqing LOU
;
Zhiren FU
;
Kang YING
;
Yi XIE
;
Yumin MAO
;
- Publication Type:Journal Article
- Keywords:
PTN gene;
cDNA microarray;
in situ hybridization;
gene expression regulation,neoplastic;
neoplasms;
etiology
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of pleiotrophin (PTN) gene in carcino genesis using cDNA microarray and in situ hybridization. Methods:The expression of PTN gene in 5 cases of glioma, 10 laryngeal squamous cell carcinoma, 6 cases of hepatocarcinoma, and normal controls were detected by BioDoor 4096 type cDNA microarray and in situ hybridization. Results: The expression of PTN gene in carcinoma samples were significantly higher than in normal controls by cDNA microarray, the results was the same as by in situ hybridization. Conclusion: cDNA microarray is an effective technique in analysis of functional study of associated genes in carcinoma. High expression of PTN gene might be correlated with mechanism of multiple carcinoma. [
