Study of the gene expression pattern of type Ⅱ diabetes related gene in Kkay mouse
- VernacularTitle:Kkay小鼠Ⅱ型糖尿病相关基因的表达谱研究
- Author:
Qinghua GUO
;
Ling YIN
;
Juming LU
;
Zhenjie ZHUANG
;
Bin ZHU
;
- Publication Type:Journal Article
- Keywords:
gene chip;
gene expression;
diabetes mellitus, non insulin dependent;
Kkay mouse
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the genes differently expressed in the livers of Kkay diabetic and normal mice, providing data to prevent human from diabetes and its chronic complications. Methods: cDNA microarray chips containing 8 192 cDNAs were used to investigate the gene expression pattern of the liver in Kkay mouse. Results: One hundred and fifty four genes were screened out, comprising 68 complete cDNAs and expressed sequence tags, among them 40 genes were up regulated and 114 genes were down regulated. Conclusion: The pathogenesis of type Ⅱ diabetes is complicated, including the disorder of the metabolism of carbohydrate, fat and protein, and many functional abnormalities of a number of vital proteins. [
