Early expression of tumor necrosis factor alpha in blood after gunshot wounds in dogs
- VernacularTitle:犬中等程度颌面枪弹伤后血中肿瘤坏死因子表达的意义
- Author:
Yang WU
;
Shuxia ZHOU
;
Xuesong LIU
;
Kun YANG
;
- Publication Type:Journal Article
- Keywords:
wounds,gunshot;
jaw;
tumor necrosis factor;
enzyme linked immunosorbent assay
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the pathophysiological role of tumor necrosis factor ? (TNF ?) and interleukin6 (IL 6) in trauma by assaying concentration of TNF ? in blood after maxillofacial gunshot wounds in dogs. Methods: Before and after gunshot wounds, concentration of TNF ? and IL 6 in the plasma of dogs were assessed by ELISA method at different times. Results: Although the systemic injuries in our gunshot wound model were no very severe and the dogs had no severe complications, the TNF ? concentration in plasma became significantly higher in the first 2 6 h after the gunshot wounds. They varied greatly with each dog and became normal after 10 h without treatment. IL 6 was not detected in blood. Conclusion: TNF ? expression in blood after gunshot wounds is the normal host immune response to the trauma, its circulating concentrations might be associated with the injury severity. But their transient expressions do not significantly increase the severity of the trauma. [
