An experimental study on permeability of basic fibroblast growth factor through placental barrier in rats
- VernacularTitle:碱性成纤维细胞生长因子对胎盘屏障通透性的实验研究
- Author:
Xiaohong HU
;
Zuo LUAN
;
Suqing QU
;
Yang RONG
;
- Publication Type:Journal Article
- Keywords:
fibroblast growth factor;
fetomaternal transfusion;
capillary permeability;
placental function tests
- From:
Academic Journal of Second Military Medical University
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate if bFGF can penetrate placental barrier. Methods: Sixteen day pregnant Wistar rats were selected. bFGF labeled with 125 I was injected peritoneally into the rats. The radioactivity of bFGF in different organs were determined in 30 min. Results: (1) 125 I bFGF was detected in the brain, heart, liver,lung and spleen. (2)With the same dose of 125 I bFGF, the concentration of it in the brain was at lowest level of all other organs.(3) In the range of safe dose, the permeability of bFGF through placental barrier was increased obviously. Conclusion: bFGF may penetrate placental barrier into rat's brain, which makes possible for the therapeutic intervention of bFGF in feotus. [
