Influence of the methionine/valine-depleted enteral nutrition on tissue distribution,nucleic acids and protein metabolism in tumor-bearing rats
- VernacularTitle:去甲硫氨酸/缬氨酸喂饲荷瘤大鼠对其在体内分布及核酸、蛋白质代谢的影响
- Author:
Yincheng HE
;
Yakui ZHOU
;
Wen LI
;
Jiwei CHEN
;
Jianguo QIAO
;
- Publication Type:Journal Article
- Keywords:
Aminoacids;
Methionine;
Valine;
DNA;
Neoplasms/experimental
- From:
Parenteral & Enteral Nutrition
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate effect of the methionine/valine(Met/Val) depleted enteral nutrition on tissue distribution,RNA,DNA and protein metabolism in tumor bearing(TB) rats. Methods:SD rats underwent catheterization of jejunostomy.A suspension of Walker 256 sarcocarcinoma cells was subcutaneously inoculated.The TB rats were randomly divided into 4 groups:A,B,C and D.The TB rats received jejunostomy feedings supplemented with balanced amino acid,methionine/valine depleted nutnition for 6 days before injection of 7.4?10 5 Bq 3H methionine/vatine.The tissue uptake and 3H Incorporation rate of radioactity into RNA,DNA and proteins in tumor tissues at 0.5,1,2,4 h after injection were assessed. Results:①Uptakes of 3H by tumor tissues in group B at 2,4 h after injection were (8.09?0.12)% and (7.81?0.17)% respectively and they were (6.59?0.24)% and (6.16?0.06)% in group A( P
