Comparing the ultrastructures of liver, kidney and lungs of ICR mice infected with chloroquine-sensitive and chloroquine-resistant strains of Plasmodium berghei
- VernacularTitle:伯氏疟原虫氯喹敏感株和抗性株感染小鼠肝、肾、肺超微结构的比较
- Author:
Keqiang CHEN
;
Guanhong SONG
;
- Publication Type:Journal Article
- Keywords:
Plasmodium berghei;
chloroquine;
pathology;
ultrastructure;
drug resistance,microbial
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate virulence differences of the malaria parasites and responses of their hosts to the malaria infection between chloroquine sensitive (N) and resistant (RC) strains of Plasmodium berghei . Methods: Ultrastructural pathological alterations of liver, kidney and lungs of ICR mice infected with the N or the RC strains were investigated. Results: Congestion and more parasite infected red blood cells in hepatic sinusoids, renal interstitium, capillaries of the liver, kidney and lungs in late period of the infection with the N strain were observed. Necrosis of hepatic cells in liver, juxtaglomerular cells and epithelial cells of renal tubules in kidney, type Ⅰ and type Ⅱ alveolar cells in lungs occurred. Membranes of these cells were broken, resulting in cytoplasm missing and mitochondria swelling infected with the N strain. While degeneration of some hepatic cells of liver, epithelial cells of renal tubules, alveoli cells of lungs appeared during late period of the infection with the RC strain of P. berghei . It was observed that some hepatic cells recoved, the glomeruli basement membrane and mesangial cells contained electron dense deposits,alveoli septa were undergoing the proliferation and infiltration of lymphocytes, macrophages and neutrophilic granulocytes. Conclusion: The N strain is more virulent than the RC strain of P. berghei . Ultrastructures of the liver, kidney and lungs of the mice infected with the N strain show cellular necrosis, while those infected with the RC strain mainly reveal cellular degeneration.
