Inhibitive effect of 981208 agent on cell proliferating of hepatocarcinogenesis induced by diethyl nitros-amine in rats
- VernacularTitle:981208冲剂抑制二乙基亚硝胺诱导的大鼠肝癌细胞增殖活性
- Author:
Yan QIAN
;
Yan JIN
;
Yuan LI
;
Changquan LING
;
- Publication Type:Journal Article
- Keywords:
agent;
Chinese Traditional Medicinion;
liver neoplasms;
cell proliferation;
chemoprevention
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the influence of 981208 agent on cell proliferaton of hepatocarcinoma induced by diethyl nitrosamine(DEN). Methods: Rat hepatocarcinogenesis model induced by DEN was established and 981208 agent was used during the stage. Influence of 981208 agent on hepatocytes positive expression of proliferating cell nuclear antigen (PCNA), H ras and bromodeoxyuridine labeling index (Brd U LI) during DEN induced rat hepatocarcinogenesis was examined by immunohistochemical method and analyzed by computerized image technique. Results: Positive expression of H ras, PCNA increased gradually and worked synergically. Overexpression of 2 proteins was inhibited significantly during DEN induced hepatcacinogenesis and Brd U LI was reduced strikingly in later stage of model by 981208 agent. Conclusion: 981208 agent can inhibit proliferating character of hepatocytes and slow down the process of hepatocarcinogenesis induced by DEN in rats.
