Special structure of extracellular Ca~(2+) -sensing receptor (CaR) and its clinical application in a new era
- VernacularTitle:细胞外钙受体的结构特点以及临床应用的新领域
- Author:
Zhengang WANG
;
Yan CHE
;
- Publication Type:Journal Article
- Keywords:
extracellular calcium sensing receptor (CaR);
calcium homeostasis;
calcium metabolic disorders;
agonist/antagonist of CaR
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The recently successful cloning of extracellular calcium sensing receptor (CaR) has revealed its vital role in adjusting and maintaining the homeostasis calcium or even other mineral ion in the body. CaR belongs to the big family of G-protein coupled receptors, and has 1079 amino acids in its structure. CaR is broadly distributed in a variety of tissues, including parathyroid, thyroid C cells, kidney, intestine and bone. So far, three disorders of extracellular calcium homeostasis have been linked with abnormalities of CaR function. Agonists and antagonists of CaR may be proved useful in the treatment of the diseases due to calcium metabolic disorders.
