Endothelium-derived hyperpolarizing factor
- VernacularTitle:血管内皮细胞超极化因子
- Author:
Dongmei CHEN
;
Hai WANG
;
- Publication Type:Journal Article
- Keywords:
endothelium dependent hyerpolarization;
nitric oxide;
potassium channels;
membrane potential;
endothelium derived relaxing factor
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
There is another factor involving in endothelium dependent relaxation besides NO, which is independent of cGMP, EDHF. Its hyperpolarization mechanism may be related to the open of calcium dependent K + channels(K + Ca). NO, PGI 2,H 2O 2 and cytochrome P450 derived metabolite of arachidonic acid are all the candidates of EDHF. In the normal blood vessels, the influence of EDHF on endothelium dependent relaxation is little. But in some diseases, when the production and effect of NO is disturbed ,the mechanism of EDHF may play a specially important role.
