Progress in study of matrix metalloproteinases and tumour invasion and metastasis
- VernacularTitle:基质金属蛋白酶与肿瘤侵袭和转移研究进展
- Author:
Xiaofeng CHEN
;
Zhenlun GU
;
- Publication Type:Journal Article
- Keywords:
marix metalloproteinases;
tumor invasion;
metastasis
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Invasion and metastasis are the distinct biological characterstics of cancer. They are the key factors influencing tumour patients' theraputic effect and prognosis. Recent study shows that metalloproteinases can facilitate tumour cell invasion and metastasis. In this review we evaluate the novel aspects of the function of matrix metalloproteinases in tumor invasion and metastasis. The regulation of the expression and activity of MMPs are summarized. The potential clinical application of metalloproteinase and their tissue inhibitors were also presented.
