Effect of puerarin on activities of cytokines secreted by neonatal cardiomyocytes during hypoxia/reoxygenation
- VernacularTitle:葛根素对缺氧-复氧时乳鼠心肌细胞分泌细胞因子的作用
- Author:
Zhitong ZHU
;
Zhi YAO
;
Jianshi LOU
;
Huiqiang LI
;
Yi LU
;
- Publication Type:Journal Article
- Keywords:
hypoxia/reoxyenation;
cardiomyocyte;
puerarin;
tumor necrosis factor ?;
interleukin 6
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effect of puerarin (Pue) on tumor necrosis factor (TNF) ?, interleukin (IL) 6 secreted by neonatal rat cardiomyocytes during hypoxia/reoxygenation injury. METHOD The activities of TNF ? and IL 6 in the supernatants of cultured myocytes, which were sampled from different groups (control, model, and therapeutic groups with 1 g?L -1 Pue, 0 1 g?L -1 Pue, 0 01 g?L -1 Pue) at different time, were assayed by bioassay method. RESULTS TNF ? and IL 6 activity increased compared with that of control ( P
