Effect of 6,7-dimethexycoumarin on tolerance to anoxia
- VernacularTitle:茵陈素的耐缺氧作用
- Author:
Yaode WAN
;
Shufen CHEN
;
Feng CHEN
;
- Publication Type:Journal Article
- Keywords:
dimethexycoumarin, tolerance hypoxia
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the protection of 6,7 dimethexycoumarin on hypoxic animals. METHODS The effect of 6,7 dimethexycoumarin on survival time and survival rate of mice subjected to hypobaric, normobaric and chemical hypoxia were observed and the oxygen consumption of isolated tissues were measured. RESULTS 6,7 dimethexycoumarin obviously prolonged the survival time and promoted the survival rate of hypoxic mice, increased the mouth opening time of isolated mice and reduced the oxygen consumption of isolated cardiac muscle of mice. This contributes to exploring the mechanism of antiradiation and poison reducing of 6,7 dimethexycoumarin. CONCLUSION 6,7 dimethexycoumarin shows remarkable effect on tolerance to hypoxia in mice.
