Effect of metabotropic glutamate receptor ligand (s)-4C3HPG on kainic acid-induced seizures and neurotoxicity in rats
- VernacularTitle:代谢型谷氨酸受体配体(s)-4C3HPG对红藻氨酸诱导性癫痫发作活动的调节研究
- Author:
Wen JIANG
;
Yuangui HUANG
;
Hongdian WANG
;
Jincun WANG
;
Hua GAO
;
- Publication Type:Journal Article
- Keywords:
metabotropic glutamate receptor;
(s)-4C3HPG;
epilepsy;
kainic acid
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To examine the effect of metabotropic glutamate receptor ligand (s) 4 carboxy 3 hydroxyphenyl glycine 〔(s) 4C3HPG〕 on kainic acid induced epileptic seizures and brain damage in rats. METHODS Rats were given (s) 4C3HPG (500 nmol/rat) by icv infusion prior to kainic acid (KA) injection ip(10 mg?kg -1 ). The behavoir changes, electrographic seizure duration and histological alterations between different group of rats were compared. RESULTS (s) 4C3HPG markedly reduced seizures severity in response to kainate. The seizure score in the rat with (s) 4C3HPG injection icv was significantly lower than that of control during the first three hours observation period after KA administration ( P
