Inhibitory effects of alendronate on osteoclastic bone resorption in vitro
- VernacularTitle:阿仑磷酸钠对体外破骨细胞性骨吸收影响的研究
- Author:
Jingtao LU
;
YANGYAN
;
Bin WANG
;
Aiwu ZHOU
;
Minzhu CHEN
;
- Publication Type:Journal Article
- Keywords:
alendronate;
osteoclasts;
bone resorption
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of alendronate sodium (Alen) on osteoclastic bone resorbing lacunae. METHOD Using the method of culturing osteoclasts on slices, the techniques of photomicrography microdensitometric scan and computer image analysis. RESULTS Alen(0 5,5 or 50 ?mol?L -1 )reduced the number and the surface area of osteoctastic bone resorbing lacunae dose dependently compared with model group there was significant defference ( P
