Inhibitory mechanisms of diazepam on macroscopic sodium currents in rat sympathetic ganglion neurons
- VernacularTitle:地西泮抑制交感神经节细胞钠通道电流的机制
- Author:
Jijian ZHENG
;
Xinliang ZHUANG
;
Dongping DU
;
Qinghong MAO
;
XUGUOHUI
;
- Publication Type:Journal Article
- Keywords:
diazepam;
sympathetic ganglion;
sodium channel;
patch clamp
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim The effects of diazepam on the whole cell sodium currents in rat sympathetic ganglion neurons were studied to investigate the mechanisms by diazepam mediates hypotension. Methods Whole cell patch clamp recordings were performed on enzymatically isolated rat superior cervical sympathetic ganglion neurons. Results Diazepam dose dependently blocked the whole cell sodium currents. Under a V t of 0 mV and a V h of 80 mV 0.3 ?mol?L -1 diazepam reduced sodium peak currents by 14.76 %(P
