Influence of anti-TNF?McAb on intestinal integrity in rats with acute pancreatitis
- VernacularTitle:抗肿瘤坏死因子?单克隆抗体对急性胰腺炎大鼠肠道完整性的影响
- Author:
Dongli CHEN
;
Weizhong WANG
;
Junyi WANG
;
Tao WANG
;
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor?;
Monoclonal antibody;
Acute pancreatitis;
Total parenteral nutrition.
- From:
Parenteral & Enteral Nutrition
1997;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To evaluate the influence of anti TNF? monocolonal antibody (anti TNF?McAb) on intestinal integrity in rats with acute pancreatitis under total parenteral nutrition. Methods:Acute pancreatitis model was induced in 32 male Sprague-Dawley rats. They were randomly divided into control group (n=16) and experiment group (n=16). Animals in control group received total parenteral nutrition (TPN). Animals in experiment group received both TPN were fed the identical TPN formula received by control group and injections of anti TNF?McAb. Rats were sacrificed on day 1 and day 5 after the induction of acute pancreatitis for measurements of intestinal permeability, absorptive capacity, mucosal wet weight, villus height and area, activities of sucrase and maltase in jejunum and bacterial translocation. Results:There was no significant difference between the two groups in intestinal permeability, absorptive capacity, mucosal wet weight, villus height and area, activities of sucrase and maltase in jejunum and bacterial translocation. Conclusions:Anti TNF?McAb has not significant influence on intestinal integrity in rats with acute pancreatitis under TPN.
