Inhibitory and excitatory effects of sodium nitroprusside on supraopticnucleus neurons in vitro
- VernacularTitle:硝普钠对离体视上核神经元的抑制和兴奋作用
- Author:
Hong_Ping HUANG
;
Meng_Ya WANG
;
- Publication Type:Journal Article
- Keywords:
sodium nitroprusside;
supraoptic nucleus;
nitric oxide;
electrophysiology
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To realize the regulatory actions of nitric oxide(NO) on supraoptic nucleus (SON)neurons by observing the effects of NO donor sodium nitroprusside(SNP) on SON neurons.Methods The cell electrophysioloical properties were obtained by the intracellular recording techniques from the SON neurons in adult rat hypothalamic slices.Results In 11 silent cells, superfusion of SNP(1 mmol?L-1) for 3～5 min resulted in the depolarization response with a decrease of membrane resistance and time constant(P
