Polysaccharide of spirulina on the prophylaxis and treatment of myelosuppression of mice caused by cyclophosphamide
- VernacularTitle:螺旋藻多糖对环磷酰胺所致小鼠骨髓抑制的实验研究
- Author:
De_Jung WANG
;
Shu_Qing SHENG
;
Rui_Qing LI
;
Yun SUN
;
Hong_Quan ZHANG
;
- Publication Type:Journal Article
- Keywords:
polysaccharide of spirulina;
myelosuppression;
cyclophosphamide;
micronuclsus;
chromosome aberration
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim The effect of polysaccharide of spirulina on mouse myelosuppression induced by cyclophosphamide was studied.Methods Mice in the model, treatment groups Ⅰand Ⅱwere given cyclophosphamide (ip 100 mg?kg-1) for there days.At the same time mice in the treatment groups Ⅰand Ⅱ were given ig spirulin 30 mg?kg-1 and 60 mg?kg-1 for ten days, while mice in the control group and model group were given ip 20 mg?kg-1 of NS.Peripheral blood and marrow cytometry, micromcelsus and chromosome aberration were analyed.Results In the dosages of 30 and 60 mg?kg-1 polysaccharide of spirulina,the polysaccharide of spirulina had perfect action on the perihemateikon and the function of bone hematoplast induced by cyclophosphamide (P
