Effect of losartan on cardiac function and secretion of nitric oxide andendothelin in patients with congestive failure
- VernacularTitle:氯沙坦对充血性心衰患者心功能及循环NO/ET的影响
- Author:
Bang_Ning WANG
;
Chuan_Huan ZHANG
;
Yu_Fang SHEN
;
Min LIU
;
Da_Nian CHEN
;
Dan_Ping GAO
;
- Publication Type:Journal Article
- Keywords:
losartan;
congestive heart failure;
endothelin;
nitric oxide
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To evalute the effects of losartan on the cardiac function and secretion of nitric oxide(NO)and endothelin(ET)in patients with congestive heart failure(CHF).Methods Sixty patients with class Ⅱ～Ⅳ CHF were randomised to receive a 12 weeks of routine therapy either with losartan(n=30)to be added from 25 mg to 50 mg daily or with enalapril(n=30)to be added from 2.5 mg to 5 mg daily. The cardiac systolic and diastolic funtion and the levels of NO and ET were observed before and after therapy respectively, with 30 normal control subjects seving as control. Results The abnormal cardiac systolic and diastolic function parameter were present in patients with CHF. The ET and NO levels in CHF patients were significantly higher than those in the control group(P
