Hyperinsulinemic Hypoglycemia Caused by Acute Reduction of Renal Function on an Eldery Patient Without Diabetes.
10.4235/jkgs.2015.19.1.34
- Author:
Jee Hyun YEO
1
;
Jeong Eun KIM
;
Eun Sik PARK
;
Jung Hwan PARK
;
Dong Sun KIM
;
Woong Hwan CHOI
;
Yoo Hun AHN
;
Ho Joong KIM
;
Sang Mo HONG
;
Chang Beom LEE
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. lekang@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Acute renal injury;
Hypoglycemia;
Hyperinsulinemia
- MeSH:
Acute Kidney Injury;
Aged, 80 and over;
C-Peptide;
Creatinine;
Diabetes Mellitus;
Energy Intake;
Epinephrine;
Female;
Glucagon;
Gluconeogenesis;
Glucose;
Humans;
Hyperinsulinism;
Hypoglycemia*;
Insulin;
Renal Insufficiency;
Renal Insufficiency, Chronic;
Seizures
- From:Journal of the Korean Geriatrics Society
2015;19(1):34-39
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In patient with renal failure, hypoglycemia may develop because of decreased caloric intake, diminished renal insulin degradation and clearance, reduced renal gluconeogenesis and hepatic glucose production, impaired release of counter-regulatory hormone such as glucagon and epinephrine. We report here on a 80-year-old female patient with hypoglycemia due to endogenous hyperinsulinemia with acute kidney injury. She had chronic kidney disease and had no history of diabetes mellitus or insulin use. She had experienced recurrent hypoglycemia despite of intravenous dextrose injection and eventually generalized tonic clonic seizure occurred as a result of hypoglycemia. As serum creatinine level decreases, serum insulin and C-peptide level decreased and hypoglycemia was not occurred. We present this case along with a review of the literature.
