STUDY  ON  THE  PROTECTIVE  EFFECTS  OF  SELENIUM  AND  ZINC  AGAINST  OXIDATIVE  DAMAGE  INDUCED  BY  SOMAN  IN  RATS

VernacularTitle:硒、锌对梭曼诱导大鼠过氧化损伤的保护机制研究
Author: Xingbin YANG ; Chunxu HAI ; Yan ZHAO ; Anji FENG ; Huixuan YANG ;
Publication Type:Journal Article
Keywords: selenium; zinc; Soman; free radical injury; T AOC
From: Acta Nutrimenta Sinica 1956;0(01):-
CountryChina
Language:Chinese
Abstract: Objective: To study the effect of free radical injury induced by Soman in rats and protection by Se/Zn. [WT5FZ]Methods: [WT5BZ]40 male rats were randomly divided into 4 groups, i.e., negative group, positive group, Se group and Zn group according to weights. The serum, cerebrum and liver VE content, nitrogen oxide synthase (NOS activity and T AOC (total antioxidative capacity) were determined. Results: The VE content and T AOC decreased markedly, and NOS activities increased significantly after Soman intoxication. The changes were less significant in Se/Zn supplemented group. Conclusion: The mechanism of free radical injury is indicated in Soman intoxication and Se/Zn supplementation has significant protection.