Effects of oxidized low density lipoprotein and antioxidant vitamin E on the expression of CD40 and CD40 ligand in cultured human monocytes
- VernacularTitle:VitE及oxLDL对人单核细胞表达CD40和CD40L的影响
- Author:
Zonggui WU
;
Jinchuan YAN
;
Lingzhen ZHANG
;
Li LI
;
Renqian ZHONG
;
- Publication Type:Journal Article
- Keywords:
oxidized low density lipoprotein;
monocytes;
CD40;
CD40 ligand;
vitamin E
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
200 ?g/L)of oxLDL markedly reduced the expression of CD40 and CD40L. When VitE was added, it significantly reduced the expression of CD40 and CD40L on monocytes surface induced by oxLDL in a dose dependent manner. Conclusion:It is an important mechanism that the high expression of CD40 and CD40L induced by oxLDL may be contributed to the formation of atherosclerosis. Antioxidan VitE can partially inhibit the high expression of CD40 and CD40L on monocytes surface induced by oxLDL. [
