Structural and functional remodeling of thoracic aortae in sinoaortic-denervated rats
- VernacularTitle:去窦弓神经大鼠的胸主动脉重构
- Author:
Xia TAO
;
Chaoyu MIAO
;
Hong CHENG
;
Dingfeng SU
;
- Publication Type:Journal Article
- Keywords:
sinoaortic denervation;
aortae;
structure;
remodeling
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the structural and functional remodeling of thoracic aortae in sinoaortic denervated (SAD) rats. METHODS SD rats underwent either SAD or sham operation at the age of 10 weeks. Sixteen weeks after operation, the contraction and relaxation of the thoracic aortae were measured in isolated preparations; The morphological changes of arteries were examined by using histopathological method and computer image analysis. RESULTS The NE induced contraction was increased and Ach induced relaxation of aortic rings was depressed in SAD rats; The structural remodeling of thoracic aortae was characterized by medial VSMC hypertrophy and matrix accumulations. CONCLUSION Vascular functional and structural remodeling can be found in sinoaortic denervated rats.
