Effect of glucocorticoid on the calmodulin mRNA of hypothalamus-pituitary-adrenal axis
- VernacularTitle:糖皮质激素对下丘脑-垂体-肾上腺轴钙调素基因表达的影响
- Author:
Chunfeng SONG
;
Guishan YIN
;
Peiyuan LU
;
Suju SUN
;
Guixiang WANG
;
- Publication Type:Journal Article
- Keywords:
calmodulin;
gene;
glucocorticoid;
hypothalamus;
pituitary;
adrenal
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of glucocorticoid acetic acid cortisone on expression of CaM mRNA in hypothalamus pituitary adrenal axis (HPAA). METHODS Using reverse transcription polymerase chain reaction (RT PCR),the expression of CaM mRNA was measured in HPAA of rats which were injected with acetic acid cortisone. RESULTS Acetic acid cortisone induced the expression of CaM mRNA in hypothalamus and adrenal respectively, but it had no effect significantly in pituitary. CONCLUSION These data suggest that CaM mRNA plays important role in the modulation of GC in HPAA.
