The relation between single or multiple dose gentamycin daily and nephrotoxicity and ototoxicity in guinea pigs
- VernacularTitle:庆大霉素给药间隔与豚鼠耳、肾毒性的关系
- Author:
Gaolin LIU
;
Haifeng SHENG
;
Yulin DENG
;
Xiaomei BAO
;
Xiufeng SHI
;
Zhenfu LIANG
;
Xuting YE
;
- Publication Type:Journal Article
- Keywords:
gentamycin;
dose;
ototoxicity;
nephrotoxici(
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare nephrotoxicity and ototoxicity of gentamycin administered in single dose or multiple dose daily in guinea pigs. Methods: Thirty two male guinea pigs were divided into physiological saline control, single dose group daily (gentamycin, 120 mg/kg, 1/d) and multiple dose group daily (gentamycin, 60 mg/kg, 2/d). The physiopathology of renal and cochlea in guinea pigs were examined using auditory brainstem response (ABR), SC sound irritation and electron microscope. The gentamycin concentrations in serum and in perilymph were monitored by fluorescene polarization immunoassay (FPIA). Results: (1) Compared with control group, both gentamycin single and mulitiple daily doses injuried kidney and cochlea to some extent.The injury of multiple dose groups were worse than that the single dose groups ( P
