Influence of histamine content in nasal mucosa of allergic rhinitis guinea-pigs on blood flow
- VernacularTitle:变应性鼻炎豚鼠鼻粘膜组胺含量对血流量的影响
- Author:
Sumin WANG
;
Ruxin ZHANG
;
Yanling YU
;
Zhaoji LI
;
Shuimiao ZHOU
;
- Publication Type:Journal Article
- Keywords:
rhinitis ,allergic;
histamine;
nasal mucosa;
blood flow [Acad J Sec Mil Med Univ, 2000, 21(12):1130 1132]
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the influence of histamine content in nasal mucosa on blood flow. Methods: Sixty guinea pigs were randomly devided into control group and allergized group and guinea pigs were sacrificed before nasal challenge with allergen and immediately after nasal challenge, at 24, 48, 72 h. The content of histamine in nasal mucosa was examined. Nasal mucosa blood flow was examined in all guinea pigs before sacrifice. The data were analyzed using linear correlation and linear regression. Results: As compared with normal guinea pigs, the content of histamine and blood flow in nasal mucosa of allergic rhinitis guinea pigs were significantly increased before challengd with allergen( P
