Histochemical changes of nitric oxide synthase in nasal mucosa of allergic rhinitis
- VernacularTitle:变应性鼻炎鼻粘膜中一氧化氮合酶的组织化学变化
- Author:
Weidong ZHOU
;
Ruxin ZHANG
;
Zhaoji LI
;
- Publication Type:Journal Article
- Keywords:
nitric oxide synthase;
rhinitis,allergic;
nasal mucosa [Acad J Sec Mil Med Univ, 2000, 21(12):1133 1134
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The activity of nitric oxide synthase(NOS)in nasal mucosa of normal guinea pigs was compared with that of allergic rhinitis(AR)guinea pigs to investigate the relationship between NOS and AR. Methods: Localization of NOS in nasal mucosa of normal and AR guinea pigs was examined by means of NADPH diaphorase (NADPH d) histochemical stain. Results: Nasal mucosa of both normal and AR groups was positive for NADPH d, though the AR group reacted more strongly. Reaction was localized to the cytoplasm of glandular cell, epithelium and vascular endothelium. Conclusion: There is distribution of NOS in nasal mucosa of normal guinea pigs. The activity of NOS in guinea pig AR model was significantly stronger than that in normal group. NOS is related to AR. [
