Effect of basic fibroblast growth factor on nerve regeneration of posterior cricoarytenoid muscle in dogs
- VernacularTitle:碱性成纤维细胞生长因子对犬环杓后肌神经再支配的作用
- Author:
Wu WEN
;
Shuimiao ZHOU
;
Xinqing YANG
;
Yongwei YU
;
Zhaoji LI
;
Qing ZHANG
;
- Publication Type:Journal Article
- Keywords:
basic fibroblast growth factor;
larynx;
muscle denervation;
nerve regeneration
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of basic fibroblast growth factor(bFGF) on nerve regeneration of the posterior cricoarytenoid muscles(PCM) in dogs. Methods: After transection of the laryngeal recurrent nerves, the denervated PCM were reinnervated by nerve muscle pedicle implantation in 9 dogs. The animals were divided into 3 groups: bFGF and fibrin glue(FG) group(bFGF+FG), FG group and control group. Functional recovery of PCM was observed laryngoscopically. Electrophysiological acvitity and muscle contract strength were determined. Histochemical studies were demonstrated by Karnovsky and H E stain. Results: Six months after operation, functional recovery and nerve regeneration of the PCA in bFGF+FG group were the best in 3 groups (close to normal), and functional recovery in FG group was better than that in control group. The parameters of electrophysiological acvitity and muscle contract strength were different in bFGF+FG group , FG group, and control group( P
