Influences of perindopril on pulmonary vascular remodeling in normobaric hypoxia-hypercapnia rats
- VernacularTitle:培哚普利对慢性缺氧高二氧化碳大鼠肺血管重建的影响
- Author:
Peng-Lin YANG
;
Lin-Sheng YU
;
Yong-Sheng GONG
;
Lu-Zhen ZHENG
;
Wei WANG
;
Liang-Gang HU
;
- Publication Type:Journal Article
- Keywords:
hypoxia;
angiotensin converting enzyme inhibitor;
perindopril;
pulmonary hypertension
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of perindopril, an angiotensin converting enzyme inhibitor, on mean pulmonary arterial pressure(mPAP) and pulmonary vascular remodeling.Methods Using the normobaric hypoxia-hypercapnia rat model,the changes of plasma angiotensin Ⅱ (Ang Ⅱ), mPAP and ultrastructure of pulmonary arteriolar wall were observed after administration of perindopril.Results The mPAP and AngⅡ were significantly greater and the ultrastructure of the small lung vessels had a more obvious change in the 4 weeks hypoxia-hypercapnia group than those in the control group.It was also found that perindopril decreased AngⅡ, declined mPAP and ameliorated vascular ultrastructure change.But the change of ultrastructure was similar in the 8 weeks hypoxia-hypercapnia group and perindopril treatment group.Conclusion It is suggested that chronic hypoxia-hypercapnia should induce the remodeling of pulmonary arteriolar structure via AngⅡ and that perindopril could ease pulmonary vascular remodeling in early stage.
