Investigation of increasing efficacy of aterial infusion of NaHCO3 to solid malignant tumors in interventional chemotherapy
- VernacularTitle:经动脉向恶性实体肿瘤组织灌注碳酸氢钠提高化疗药物疗效的初步观察
- Author:
Ping-Sheng FAN
;
Yu-Xiu WAN
;
Ji-De LI
;
Hu BEI
;
Ke-Hai FENG
;
Shi-Ceng WANG
;
Xin-Min LI
;
Ru-Hua LIU
;
Li-Yuan HU
;
- Publication Type:Journal Article
- Keywords:
NaHCO3;
adriamycin;
mitomycin;
5-fluorouracil;
aterial infusion
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effect of interventional therapy of 5-fluorouracil(5-Fu), mitomycin C (MMC) and adriamycin (ADM) on solid malignant turmors in association with aterial infusion of NaHCO3.Methods Patients were randomly divided into two groups.With Seldinger technique,through the femoral atery to tumor atery.The patients in the control group were infused by anticarcinoma agents simply ,and patients in the treatment group were initially infused by NaHCO3,and then by NS 30 ml and anticarcinoma agents seperately. Results Partial remission (PR) in the group treated with NaHCO3 and anticarcinoma agents was significantly higher than in the group treated simply with anticarcinoma agents.Conclusion Aterial infusion of NaHCO3 into malignant tumors can increase the efficacy of ADM,MMC and 5-Fu.
