The protective effect of NEPC on the ultra-structure and cardiac function of ischemic/reperfused rat heart
- VernacularTitle:去甲肾上腺素预处理对缺血/再灌注大鼠心脏超微结构、心功能的保护作用
- Author:
Hanqiao ZHENG
;
Chuanren DONG
;
Yanzhen LU
;
Youyun ZHANG
;
Chunyan MA
;
Shuzhen TU
;
Jingping OUYANG
;
- Publication Type:Journal Article
- Keywords:
ischemic preconditioning;
norepinephrine;
rat;
heart;
ischemia/reperfusio
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To compare the protective effects of norepinephrine preconditioning(NEPC)and ischemic preconditioning(IPC)on myocardial ischemic/reperfused injury in rats in vivo . METHODS Rats were divided into control, ischemia/ reperfusion, classic IPC and NEPC groups. After 20 min reperfusion, several indexes including cardiac function indexes, MDA were tested, the myocardial ultrastr ucture and the injury reaction of catalase observed. RESULTS Both IPC and NEPC could protect myocardial ultra structure, ameliorate left heart function, decrease cardiac MDA content and protect the activity of catalase. CONCLUSION Extra micro norepinephrine preconditioning as a non injury method can mimic the protective effects of classic IPC and shows its clinical values.
