Role of K_(ATP) on the reduction of blood pressure variability caused by adenosine in sinoaortic denervated rats
- VernacularTitle:K_(ATP)在腺苷降低去窦弓神经大鼠血压波动性中的作用
- Author:
Fuming SHEN
;
Dingfeng SU
;
- Publication Type:Journal Article
- Keywords:
sinoaortic denervated;
blood pressure variability;
ATP sensitive potassium channel;
adenosix
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the effect of K ATP on the reduction of blood pressure variability (BPV) caused by adenosine in conscious, freely moving sinoaortic denervated (SAD) rats. Methods: Using computerized analytic system of blood pressure (BP), five groups treated with adenosine, adenosine A 1 receptor agonist N 6 cyclopentyladenosine (CPA), A 2 receptor agonist 5′ N cyclopropyl carboxamido adenosine (CPCA), ATP sensitive K + channel (K ATP ) blocker glibenclamide, and CPCA with the K ATP blocked by glibenclamide in advance were used. BP, heart period (HP) and BPV were analyzed. Results: Both adenosine and CPCA significantly decreased BPV in SAD rats, but CPA had no influence on it. Glibenclamide markedly reduced BPV in SAD rats as well, furthermore, it might antagonize the effect of CPCA on BPV by blocking K ATP . Conclusion: K ATP plays an important role in the development of high BPV in SAD rats. [
