Impurity limit test of raw material of ciprofloxacin by high performance capillary electrophoresis
- VernacularTitle:高效毛细管电泳法用于环丙沙星原料药的杂质限量分析
- Author:
Cha YIN
;
Yutian WU
;
- Publication Type:Journal Article
- Keywords:
ciprofloxacin;
electrophoresis, high performance capillary;
impurity limit te
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To develop a high performance capillary electrophoresis(HPCE) method for the impurity limit test of raw material of ciprofloxacin. Methods: An optimal method was established by studying on pH value, sampling time and other electrophoretic conditions. Results: The RSD of migration time was 0.23% and of the peak area was 2.49%. The limit of detection was 1.21 ?mol/L. The impurity profile and content was consistent with the dilution of sample concentration. Conclusion: HPCE method proves to be suitable for impurity limit test of raw material of ciprofloxacin. [
