Study on the permeability of leflunomide in vitro
- VernacularTitle:来氟米特离体透皮吸收的研究
- Author:
Quangang ZHU
;
Jinhong HU
;
Huajun SUN
;
- Publication Type:Journal Article
- Keywords:
leflunomide;
liposome;
percutaneous absorption
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the permeability of leflunomide and the effect of liposome on its permeability. Methods: Modified Franz diffusion cell adopted as apparatus for in vitro skin permeation. Various excised skins were used as permeation barriers and permeation coefficient was used as index. The concentration of leflunomide in the samples was measured by HPLC. Results: Leflunomide had a good permeability, but the effect of liposome on permeability was not very strong. Conclusion: It is feasible that leflunomide is applied through skin. [
