Study on pharmacokinetics and bioavailability of verapamil hydrochloride pulsed-release tablets in volunteers
- VernacularTitle:盐酸维拉帕米脉冲控释片人体内的药代动力学及生物利用度研究
- Author:
Hao ZOU
;
Tao GUO
;
Xuetao JIANG
;
Yin SUI
;
Jianping ZHOU
;
- Publication Type:Journal Article
- Keywords:
verapamil hydrochloride;
delayed action preparations;
pharmacokinetics;
bioavailability
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the pharmacokinetics and bioavailability of verapamil hydrochloride pulsed release tablets with core tablets. Methods: Latin test was employed in the single oral administration of the Ⅲ,Ⅳ type of pulsed release tablets and core tablets in 8 volunteers. The pharmaceutics behavior of the tablet in vivo was evaluated by the lag time, c max ,AUC and so on. Results: The pharmacokinetics results demonstrated that the Ⅲ type of pulsed tablet in humans could be released after about 4 h lag time. In a proper range, pulsed release tablets only changed the beginning time while c max and AUC were not different from the core tablets. Conclusion: A new system to reduce the early morning symptoms of ischemic heart disease is prepared. [
