Pharmacokinetics of diclofenac sodium microemulsions in rabbits
- VernacularTitle:双氯芬酸钠微乳的家兔体内药代动力学考察
- Author:
Ying LU
;
Xuetao JIANG
;
Renjie ZENG
;
- Publication Type:Journal Article
- Keywords:
diclofenac sodium microemulsions;
pharmacokinetics;
chromatography high performance liquid
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the pharmacokinetic progress of diclofenac sodium microemulsions in rabbits. Methods: Diclofenac sodium microemulsion and diclofenac sodium suspension were single orally given to rabbits. Diclofenac sodium concentrations in plasma were measured by HPLC method. Results: AUC 0 ∞ , c max1 and t max1 were 13.456 ?g?h?ml -1 , 2.852 ?g/ml and 1.438 h after po diclofenac sodium microemulsion and 10.584 ?g?h?ml -1 , 3.145 ?g/ml and 0.750 h after po diclofenac sodium suspension. Conclusion: The absorption of diclofenac sodium microemulsions in rabbits is slower and can keep a higher concentration in plasma for a long time compared with those of the suspension. [
