Experimental studies on the protective effect of defibrase againstreperfusion injury after cerebral ischemia
- VernacularTitle:降纤酶对大鼠脑缺血再灌注损伤保护作用的实验研究
- Author:
Ru-Xun HUANG
;
Xiao-Hua XIAO
;
Mei YIN
;
Ling LI
;
Hua LI
;
Zheng-Pei SU
;
- Publication Type:Journal Article
- Keywords:
reperfusion after cerebral ischemia;
defibrase;
rat
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To ascertain whether defibrase has the protective effect against reperfusion injury after cerebral ischemia.Methods 70 renovascular hypertensive rats(RHR) were randomly divided into defibrase group, control group and sham-operated group.Reversible middle cerebral artery occlusion(MCAO) models were produced by the modified. Longa's method,and reperfusion was begun 2 hours after occlusion.Rats in the defibrase group were given defibrase 10 U?kg-1 body weight via femonal intraveneous injection, and in the control group with the same amount of saline. The brain pieces were processed by TTC and HE staining and the infarct size,brain microvessels damage and secondary bleeding were compared between the two groups. Results The volume of infarction in the defibrase group was obviously smaller than in the control group, the damage of brain microvessels was less severe, and the bleeding lesions under optical microscope were less than in the control group. Conclusion Defibrase has protective effect against reperfusion injury post cerebral ischemia.
