Study tetrandrine defer extraceller matrix mechanism
- VernacularTitle:汉防己甲素延缓肾小球硬化机理的实验研究
- Author:
Xing-Gang DONG
;
Ming LU
;
Hai-Chun YANG
;
He-Xing CAO
;
Dong-Sheng ZHU
;
Chuan-Ji YE
;
Ming-Hua XU
;
- Publication Type:Journal Article
- Keywords:
tetrandrine;
transforming growth factor-?1;
glomerulosclerosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim The effect of tetrandrine on TGF-?1 mRNA expression in glomerulosclerosis rat was observed. Methods The rats were randomly divided into four groups, such as the normal control group (sham operative rat), glomerulosclerosis model group,tetrandrine group and amlodipine group. The expression of TGF-?1 mRNA was analyzed by Northern blot hybridization. Results The expressions of TGF-?1 mRNA in two treating groups were much lower than untreated model group. There were no difference between these two treating groups. Conclusion Tetrandrine can decrease the expression of TGF-?1 mRNA in glomerulosclerosis rat induced by unilateral renctomy plus adriamycin.
