Pharmacokinetics of dauricine in dogs
- VernacularTitle:蝙蝠葛碱犬体内药代动力学研究
- Author:
Shu-Juan CHEN
;
Bin ZHANG
;
Yi-Mei YANG
;
Zong-Shun DAI
;
Fan-Dian ZENG
;
- Publication Type:Journal Article
- Keywords:
dauricine;
pharmacokinetics;
RP-HPLC
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
K21. The mean t1/2(?) was (2.7?0.4) h, Vd was about 11.18 L?kg-1.The C-T profile conformed to two compartment open model. The plasma Dau concentration-time curves showed a double-peak phenomenon in all dosages of all dogswhen dauricine was given by intragastric was.The tpeak(1) was (0.8?0.6) ～(1.2?0.5) h,tpeak(2) was (5.2?3.2) ～(6.5?1.9)h,Cmax(2) 0.05) and the AUC was increased in proportion.The drug is eliminated non-linearly when the dosage is above 50 mg?kg-1, the parameters t1/2(el),CL, AUC/X0 shows great difference (P
